Metabolic findings in a patient with hyperosmolar non-ketoacidotic diabetic stupor.

Hyperosmolar non-ketotic diabetic coma and rhabdomyolysis.

Rhabdomyolysis is a rare but potentially fatal complication of hyperosmolar states. We report a case of severe hyperosmolar non-ketotic diabetic coma causing rhabdomyolysis in a young man. Despite very high levels of creatine kinase there was no detectable myoglobinuria. Creatine kinase estimation should be a standard investigation in all patients presenting with a hyperosmolar state.

Hyperosmolar non-ketotic diabetic syndrome precipitated by treatment with diuretics.

The hyperosmolar non-ketotic diabetic syndrome, first reported in 1957,' is being diagnosed with greater frequency.' Several cases have been reported of this syndrome being precipitated by treatment with diuretics, especially thiazide diuretics and frusemide.3-9 Diuretic treatment lasted from 15 days4 to 4 years" before the syndrome developed. We reviewed the case notes of a consecutive series ...

Muscle glutamine production in diabetic ketoacidotic rats.

The mechanism of activation of glutamine production by the hindlimb during diabetic ketoacidosis (DKA) was investigated in rats. Muscle glutamine production was estimated to account for over 90% of the total glutamine produced by the hindlimb. DKA produced significant increases in the concentrations of NH4+ and IMP in hindlimb muscles, suggesting that AMP deaminase is activated by DKA. NH4Cl- a...

Extensive venous thrombosis of the upper extremity in a diabetic patient with a hyperosmolar hyperglycemic state

We report a case of extensive venous thrombosis of the upper extremity in a patient with a hyperosmolar hyperglycemic state (HHS). Thrombosis of the upper extremities is generally found in 4% of cases with deep venous thrombosis. Extensive, symptomatic venous thrombosis of the upper extremity, as seen in this patient, is rare except with catheter-related thrombosis. Recent studies have supporte...

Hyperglycemic diabetic stupor: a spectrum of disorders.